Research Article

Management and governance structure of technology transfer megaprojects in emergency contexts: a case study of the megaproject Oxford/AstraZeneca/Fiocruz Covid-19 vaccine

Priscila Ferraz Soares; Mauricio Zuma Medeiros; Jaqueline Lilge Abreu; Fabio Henrique Ferreira dos Santos Gonçalez; Fabio Sartori Piran

Downloads: 0
Views: 39


Paper aims: We analyze in this study the management and governance structure of technology transfer in megaprojects under an emergency context.

Originality: We analyze an emergency health megaproject's management and governance structure. There is a dearth of studies that explore the management and governance structure of combination megaprojects in emergencies. We focus on analyzing the literature and the management and governance structure in the technology transfer, production, and supply of the Covid-19 vaccine. We then develop a reference model for building the management and governance structure of megaprojects in emergencies.

Research method: We conducted a case study in Bio-Manguinhos/Fiocruz. From the case study, we can analyze real situations that contribute to the development of theories. For this, we systematically reviewed the literature to identify how the megaproject management structure has been used. We interviewed stakeholders of the Oxford/AstraZeneca/Fiocruz vaccine megaproject against Covid-19 and triangulated these data by collecting corresponding documents.

Main findings: We conclude that the management and governance structure of the Oxford/AstraZeneca/Fiocruz vaccine technology transfer, production, and supply megaproject was appropriate. Since this structure should not be reproduced faithfully due to its specific characteristics, we developed a reference model for structure building in emergencies. This model can support institutions and governments in structuring management and governance in critical situations.

Implications for theory and practice: The knowledge obtained from this study will contribute to determining management and governance structures for future megaprojects, especially in emergencies.


Vaccine, COVID-19, Megaprojects, Project management and governance


Abelin, A., Colegate, T., Gardner, S., Hehme, N., & Palache, A. (2011). Lessons from pandemic influenza A(H1N1): the research-based vaccine industry’s perspective. Vaccine, 29(6), 1135-1138. PMid:21115061.

Barbosa, A. P. R., Homma, A., Couto, A. R., & Teles, E. M. F. (2014). From vaccines and in vitro diagnostic reagents to similar biotherapeutics production in Brazil: a case study. Journal of Generic Medicines, 11(3-4), 129-135.

Bardin, L. (2012). Análise de conteúdo. Lisbon: Edições 70.

Brasil. Ministério da Saúde. (2020). Plano nacional de operacionalização da vacinação contra a COVID-19. Brasília: Ministério da Saúde.

Brunet, M., & Forgues, D. (2019). Investigating collective sensemaking of major project success. International Journal of Managing Projects in Business, 12(3), 644-665.

Dubé, L., & Paré, G. (2003). Rigor in information systems positivist case research: current practices, trends, and recommendations. Management Information Systems Quarterly, 27(4), 597-635.

Ermel, A. P. C., Lacerda, D. P., Morandi, M. I. W. M., & Gauss, L. (2021). Literature reviews: modern methods for investigation scientific and technological knowledge. Cham: Springer.

Eweje, J., Turner, R., & Müller, R. (2012). Maximizing strategic value from megaprojects: the influence of information-feed on decision-making by the project manager. International Journal of Project Management, 30(6), 639-651.

Feger, A. L. R., & Thomas, G. A. (2012). A framework for exploring the relationship between project manager leadership style and project success. International Journal of Management, 1(1), 1-19.

Fialho, B. C., Gauss, L., Soares, P. F., Medeiros, M. Z., & Lacerda, D. P. (2023). Vaccine innovation meta-model for pandemic contexts. Journal of Pharmaceutical Innovation, 1-49. In press. PMid:36818394.

Flyvbjerg, B. (2014). What you should know about megaprojects and why: an overview. Project Management Journal, 45(2), 6-19.

Flyvbjerg, B. (2017). The Oxford handbook of megaproject management. Oxford: Oxford University Press.

Forman, R., Shah, S., Jeurissen, P., Jit, M., & Mossialos, E. (2021). COVID-19 vaccine challenges: what have we learned so far and what remains to be done? Health Policy, 125(5), 553-567. PMid:33820678.

Friede, M., Palkonyay, L., Alfonso, C., Pervikov, Y., Torelli, G., Wood, D., & Kieny, M. P. (2011). WHO initiative to increase global and equitable access to influenza vaccine in the event of a pandemic: supporting developing country production capacity through technology transfer. Vaccine, 29(Suppl. 1), A2-A7. PMid:21684422.

Fundação Oswaldo Cruz. (2022). Produção, efetividade e segurança da vacina. Rio de Janeiro: FIOCRUZ. Retrieved in 10 April 2023, from,que%20n%C3%A3o%20houve%20interna%C3%A7%C3%B5es%20hospitalares

Funk, C. D., Laferrière, C., & Ardakani, A. (2020). A snapshot of the global race for vaccines targeting SARS-CoV-2 and the COVID-19 pandemic. Frontiers in Pharmacology, 11, 937. PMid:32636754.

Furlaneto, A. (2020). Campeã de vacinas na América Latina, Bio-Manguinhos se adapta para enfrentar a Covid. Rio de Janeiro: O Globo. Retrieved in 10 April 2023, from

Gadelha, C. A. G., Braga, P. S. C., Montenegro, K. B. M., & Cesário, B. B. (2020). Acesso a vacinas no Brasil no contexto da dinâmica global do Complexo Econômico-Industrial da Saúde. Cadernos de Saúde Pública, 36(Suppl. 2), e00154519. PMid:32876097.

Gellert, P. K., & Lynch, B. D. (2003). Megaprojects as displacements. International Social Science Journal, 55(175), 15-25.

Hamidi, A., Boog, C., Jadhav, S., & Kreeftenberg, H. (2014). Lessons learned during the development and transfer of technology related to a new Hib conjugate vaccine to emerging vaccine manufacturers. Vaccine, 32(33), 4124-4130. PMid:24923635.

Hendriks, J. (2012). Technology transfer in human vaccinology: a retrospective review on public sector contributions in a privatizing science field. Vaccine, 30(44), 6230-6240. PMid:22902679.

Instituto de Tecnologia em Imunobiológicos. Fundação Oswaldo Cruz. (2020a). Boletim semanal coronavírus. Rio de Janeiro: Bio-Manguinhos/FIOCRUZ. Edition 16.

Instituto de Tecnologia em Imunobiológicos. Fundação Oswaldo Cruz. AstraZeneca. (2020b). Termo de contrato de encomenda tecnológica N°1/2020. Retrieved in 10 April 2023, from

Kardes, I., Ozturk, A., Cavusgil, S. T., & Cavusgil, E. (2013). Managing global megaprojects: complexity and risk management. International Business Review, 22(6), 905-917.

Li, Y., Han, Y., Luo, M., & Zhang, Y. (2019). Impact of megaproject governance on project performance: dynamic governance of the Nanning transportation hub in China. Journal of Management Engineering, 35(3), 05019002.

Lurie, N., Saville, M., Hatchett, R., & Halton, J. (2020). Developing Covid-19 vaccines at pandemic speed. The New England Journal of Medicine, 382(21), 1969-1973. PMid:32227757.

Medeiros, M. Z., Soares, P. F., Fialho, B. C., Gauss, L., Piran, F. S., & Lacerda, D. P. (2022). Vaccine innovation model: a technology transfer perspective in pandemic contexts. Vaccine, 40(33), 4748-4763. PMid:35773123.

Miguel, P. A. C. (2007). Estudo de caso na engenharia de produção: estruturação e recomendações para sua condução. Production, 17(1), 216-229.

Miyaki, C., Meros, M., Precioso, A. R., & Raw, I. (2011). Influenza vaccine production for Brazil: a classic example of successful North-South bilateral technology transfer. Vaccine, 29(Suppl. 1), A12-A15. PMid:21684420.

O’Sullivan, C., Rutten, P., & Schatz, C. (2020). Why tech transfer may be critical to beating COVID-19. New York: McKinsey & Company. Retrieved in 10 April 2023, from

Piran, F. S., Lacerda, D. P., Camanho, A. S., & Silva, M. C. (2021). Internal benchmarking to assess the cost efficiency of a broiler production system combining data envelopment analysis and throughput accounting. International Journal of Production Economics, 238, 108173.

Plotkin, S. A., Orenstein, W. A., Offit, P. A., & Edwards, K. M. (2018). Plotkin’s vaccines (7th ed.). Philadelphia: Elsevier.

Sanderson, J. (2012). Risk, uncertainty and governance in megaprojects: a critical discussion of alternative explanations. International Journal of Project Management, 30(4), 432-443.

Souza, I. G., Lacerda, D. P., Camargo, L. F. R., Dresch, A., & Piran, F. S. (2018). Do the improvement programs really matter? An analysis using data envelopment analysis. BRQ Business Research Quarterly, 21(4), 225-237.

van Marrewijk, A., & Smits, K. (2016). Cultural practices of governance in the Panama Canal expansion megaproject. International Journal of Project Management, 34(3), 533-544.

van Marrewijk, A., Clegg, S. R., Pitsis, T. S., & Veenswijk, M. (2008). Managing public-private megaprojects: paradoxes, complexity, and project design. International Journal of Project Management, 26(6), 591-600.

Velho, S. R. K., Simonetti, M. L., Souza, C. R. P., & Ikegami, M. Y. (2017). Nível de maturidade tecnológica: uma sistemática para ordenar tecnologias. Parcerias Estratégicas, 22(45), 119-140.

Wang, W., Fu, Y., Gao, J., Shang, K., Gao, S., Xing, J., Ni, G., Yuan, Z., Qiao, Y., & Mi, L. (2021). How the COVID-19 outbreak affected organizational citizenship behavior in emergency construction megaprojects: case study from two emergency hospital projects in Wuhan, China. Journal of Management Engineering, 37(3), 04021008.

World Health Organization. (2011). Pharmaceutical production and related technology transfer. Geneva: WHO.

World Health Organization. (2013). Vaccine safety. Geneva: WHO. Retrieved in 10 April 2023, from

Zhai, L., Xin, Y., & Cheng, C. (2009). Understanding the value of project management from a stakeholder’s perspective: case study of mega- project management. Project Management Journal, 40(1), 99-109.

Submitted date:

Accepted date:

645cf772a9539520280886f8 production Articles
Links & Downloads


Share this page
Page Sections